• Distribution of histamine receptors in

  2022-05-05

  

  Distribution of histamine receptors in the intestines varies among species, but our findings are similar to those previously reported in humans and guinea pigs (Thurmond, 2010, Thurmond, 2015). H1 receptors were located mainly in the gastric mucosa, smooth muscle, and lymphoid tissue, corresponding

• Histamine functions as a key neurotransmitter in multiple ci

  2022-05-05

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, histamine is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway

• E3330 br HO and cerebral malaria In a post

  2022-05-04

  

  HO-1 and cerebral malaria In a post-mortem evaluation of human cerebral (falciparum) malaria, strong HO-1 immunostaining was consistently noted in microglia/macrophages within and surrounding the pathognomonic Durck’s granulomas (Schluesener et al., 2001). As witnessed in cerebral trauma specimen

• br GSNOR regulates SA synthesis and SA signalling

  2022-05-04

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic MRS 1220 synthesis (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal r

• Crystal structures from soluble E constructs

  2022-05-04

  

  Crystal structures from soluble E2 constructs (Khan et al., 2014; Kong et al., 2013) have revealed globular protein with no regular structure in spite of having eight disulphide bonds (Kong et al., 2013). Although 62% of the protein exists in loops or disordered structures, overall it was well-defin

• br Conclusion br Conflict of interest

  2022-05-04

  

  Conclusion Conflict of interest statement Acknowledgements This work was supported by the National Science Foundation (MCB-1817417 to S.D.) and National Institutes of Health (R01-GM72711 to A.C.D.). We thank members of the Delaney laboratory for careful reading of the manuscript and helpful

• Previously localization studies have been conducted using an

  2022-05-04

  

  Previously, localization studies have been conducted using antibody-based detection of Pgp protein in tissues of Clade V nematodes. In transgenic C. elegans, Cel-Pgp-3 and Cel-Pgp-1 proteins localized to the apical membranes of the excretory and intestinal cells and the anterior pharynx (Broeks et a

• To further implicate the role of EAAT in

  2022-05-04

  

  To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 GNE-317 was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA but not in the hippocampus of wild-type mice at

• Docetaxel MicroRNA or miRNA is group of RNA molecule of

  2022-05-04

  

  MicroRNA, or miRNA, is group of RNA molecule of about 22 nucleotides without protein-coding function. MicroRNAs are widely distributed in plants, animals and even some viruses and participant in both normal physiological and pathological processes by post-transcriptional regulation of gene expressio

• br Glucocorticoid receptor and metabolic syndrome GCs acting

  2022-05-04

  

  Glucocorticoid receptor and metabolic syndrome GCs acting through the GR regulate key enzymes of glucose metabolism in the liver, skeletal muscle, adipose tissue and the pancreas. In the liver, GCs regulate the expression of major gluconeogenic enzymes such as phosphoenolpyruvate carboxykinase, g

• SC 79 We are aware that the classical

  2022-05-04

  

  We are aware that the classical biochemical view is centered on the local concentrations of specific ion and molecules rather than on cell electric potentials. However, important downstream processes can be influenced by acting locally on these potentials because they regulate the conductance of the

• To date the underlying mechanism of ropivacaine

  2022-04-29

  

  To date, the underlying mechanism of ropivacaine in inducing neurotoxicity remains unclear. Cell death was intimately involved in local-anesthetic neurotoxicity [6,18]. Two classic signaling pathways triggered cell death: the extrinsic pathway and the intrinsic pathway [12]. Our study demonstrated t

• FDP is considered as key intermediate in the isoprenoid bios

  2022-04-29

  

  FDP is considered as key intermediate in the isoprenoid biosynthetic pathway, since it is the common precursor of polyisoprene units and farnesylated proteins (Cao et al., 2012). In order to understand the role of FDP gene in rubber-producing plants it is of critical importance to Z DEVD FMK and cha

• In addition JMJ proteins respond to biotic

  2022-04-29

  

  In addition, JMJ proteins respond to biotic stress and abiotic stress in plants. Rice genes OsJMJ704 and OsJMJ705, which have demethylase activities of H3K27me2/3 and H3K4me2/3, respectively, regulate defense-related genes and affect the defense ability of rice against bacterial pathogen Xoo (Li et

• hydroxychloroquine sulfate There were hub genes identified b

  2022-04-29

  

  There were 11 hub genes identified by WGCNA among which KIBRA was the hub gene of the black module. The bioinformatics method is an effective and powerful tool to analyze mRNA hydroxychloroquine sulfate profiles and the related pathways. For instance, the lung cancer risk modules that were closely

15983 records 468/1066 page Previous Next First page 上5页 466467468469470 下5页 Last page